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  • The Chemistry Research Solution LLC
    ADCs or PDCs which include Dolastatin 10 and Auristatin analogs Duocarmycin analogs Maytansine analogs PBD dimer analogs TCRS can also design and synthesise customised potent cytotoxic compounds and payloads with linkers TCRS conducts all work with highly toxic cytotoxic compounds and payloads in its specially designed containment laboratory which is accessible only to authorized and trained TCRS chemists This laboratory has an independent air handling HVAC system and is equipped

    Original URL path: http://www.tcrs.us/payloads.php (2016-04-27)
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  • The Chemistry Research Solution LLC
    and a proven track record of producing active drug candidates in a variety of therapeutic areas including infectious disease cardiovascular inflammation and oncology that have reached advanced testing We will work closely with your chemists and biologists to advance your drug discovery efforts Custom Synthesis Manufacture Medicinal Chemistry Our team includes accomplished chemists from the pharma industry Combination of experience and modern tools to deliver potential clinical candidates Rapid and

    Original URL path: http://www.tcrs.us/small-molecules.php (2016-04-27)
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  • The Chemistry Research Solution LLC
    scale Common requests include chemical intermediates drug metabolites process impurities degradants reference compounds preclinical drug candidates and other organic molecules from diverse industries Our Custom Synthesis expertise includes Antibody drug conjugates ADCs Bioconjugate chemistry Linker Chemistry Carbohydrate chemistry including glucuronides Catalytic hydrogenation Chiral synthesis and separations General organic and small molecule synthesis Macrolides Metabolites impurities Organometallic chemistry Oxidations Peptide amino acid synthesis Polycyclic aromatic hydrocarbons Photochemistry Pressure reactions Stable isotopes

    Original URL path: http://www.tcrs.us/custom-synthesis.php (2016-04-27)
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  • The Chemistry Research Solution LLC
    manufacturability World wide sourcing for best quality and cost Manufacturing Non GMP batches for toxicology studies In house manufacturing up to 100g Full batch records for regulatory submissions Tech transfer for multi kg GMP scale High Potency Capacity of 25 100 grams for highly potent and cytotoxic small molecules A 5 band system of classifying risk is in place for highly potent compounds Band 1 1 mg 10 mg m

    Original URL path: http://www.tcrs.us/manufacturing.php (2016-04-27)
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  • The Chemistry Research Solution LLC
    manufacturing laboratory a antibody drug conjugate laboratory an analytical laboratory Overall our laboratories contain 28 fume hoods 12 walk in hoods 3 biological safety hoods and a canopy hood suitable for 50L to 100L reactors Equipment Our in house equipment includes Two 500 MHz NMR spectrometers Varian Inova with Agilent VNMRj 3 2 software 300 MHz Varian Inova multi probe 1H 13C 19F 11B 31P 15N NMR system with auto sampler and Agilent VNMRj 3 2 software Shimadzu Biotech Axima Confidence MALDI Tof Agilent 1100 1200 LC MS systems Agilent 7890 GC MS with headspace analysis Hitachi U 2900 Photospectrometer Preparative HPLC systems Bio inert HPLCs AKta FPLC Isco CombiFlash purification systems 20 L and 4 L jacketed glass reactors with stirrer and cooling heating systems 20 L rotary evaporator Continuous flow hydrogenation reactors H Cube and H Cube Midi Flow reactor ThalesNano X Cube Photochemical reactor Polarimeter Labconco FreeZone lyophilizers VirTis Sentry 2 0 freezemobile Harris 80 C freezer Parr hydrogenation apparatuses Flow Sciences ventilated weigh enclosures Plas Labs 830 Series Compact Glove Box closed loop containment Microwave synthesizers Kugelrohr distillation apparatus Centrifuges Stability chambers U S Filter Ozone Generator Model T 816 Veolia Purelab Flex Elga water purifier

    Original URL path: http://www.tcrs.us/facilities.php (2016-04-27)
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  • The Chemistry Research Solution LLC
    reports and technical documents Strong laboratory bench skills are required Analytical Chemist full time This position requires a BS MS or PhD degree in analytical or organic chemistry Experience working as an analytical chemist in a contract research or pharmaceutical laboratory is preferred but recent graduates are also welcome to apply The analytical chemist will have hands on experience with HPLC analytical and preparative and LC MS as well as a thorough knowledge of analytical instrumentation and equipment Prior work experience in a GMP regulated work environment is mandatory while familiarity with Varian NMR spectrometers would be considered a plus The analytical chemist will provide a full range of analytical services to TCRS s chemistry group as well as to the company s clients Other duties include maintenance and trouble shooting of instruments issuance and implementation of SOPs analytical method development and validation IQ OQ of raw materials and API impurity profiling impurity isolation and identification conduct stability studies according to ICH guidelines prepare analytical data of the CMC section of an IND qualification of instruments and cleaning verifications If you are interested in working for TCRS and want to make a big impact in a small company work environment

    Original URL path: http://www.tcrs.us/careers.php (2016-04-27)
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  • The Chemistry Research Solution LLC
    Larger Map From Philadelphia and Points South Take Interstate 95 North towards Trenton New York City Take Exit 40 PA Rt 413 South Bristol Merge onto PA Route 413 South far right lane Follow PA Route 413 through several lights Go over Route 13 and bear right towards the Burlington Bristol Bridge Immediately turn left at Rohm Haas Drive into the Bridge Business Center Turn right at George Patterson Blvd Go around the bend past ACE Designs TCRS will be on the right in the 360 building The main office of TCRS is located in Suite 101E From Norristown Take the Pennsylvania Turnpike towards New Jersey Take exit 358 for US 13 toward Levittown Bristol Delaware Valley the last exit in Pennsylvania Keep right at the fork to continue toward Bristol Pike US 13 S and merge onto Bristol Pike US 13 S Continue on Rt 13 for approximately 2 miles Beyond the traffic light at Rt 413 Wal Mart is on your right make a right jug handle turn and proceed over Rt 13 Go under the railroad bridge and bear right towards the Burlington Bristol Bridge Immediately turn left at Rohm Haas Drive into the Bridge Business Center Turn right at George Patterson Blvd Go around the bend past ACE Designs TCRS will be on the right in the 360 building The main office of TCRS is located in Suite 101E From Trenton Take Route 1 South to US 13 S toward Levittown Bristol Continue on Rt 13 for approximately 10 miles Beyond the traffic light at Rt 413 Wal Mart is on your right make a right jug handle turn and proceed over Rt 13 Go under the railroad bridge and bear right towards the Burlington Bristol Bridge Immediately turn left at Rohm Haas Drive into the

    Original URL path: http://www.tcrs.us/contact.php (2016-04-27)
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